ANCA-negative Pauci-immune crescentic glomerulonephritis with thrombotic microangiopathy.

Dear Editor, Pauci-immune crescentic glomerulonephritis (Pauciimmune CGN) is the most common cause of CGN. Thrombotic microangiopathy (TMA) defi nes a clinicopathological syndrome consisting of intraluminal platelet thrombosis in the microvasculature and the presence of fragmented red blood cells and thrombocytopaenia in the peripheral blood, and may be seen in haemolytic uraemic syndrome (HUS), thrombotic thrombocytopaenic purpura (TTP) and other conditions. Co-existence of TMA and pauciimmune CGN is rare. We describe a case of anti-neutrophil cytoplasmic antibody (ANCA)-negative pauci-immune crescentic glomerulonephritis with microangiopathic haemolytic anaemia and histopathological evidence of TMA.